Prof. Anat Mirelman, PhD is a professor at Sackler School of Medicine and Sagol School of Neuroscience at Tel Aviv University and is the director of the Laboratory for Early Markers of neurodegeneration (LEMON). In her research, she is privileged to address questions relating to motor and cognitive function in ageing and disease, understanding mechanisms of neurodegeneration and exploring sensitive measures to detect early functional decline. Prof. Mirelman has been leading the Genetics in Parkinson’s disease Project since 2007. The goal of this project is to identify early subtle clinical markers that could indicate disease processes. As such clinical, imaging, biological and digital markers are evaluated in populations at risk based on genetic mutations as measures of disease and disease progression. To date this cohort includes more than 3000 participants and is considered one of the largest genetic PD cohorts in the world. Using digital technologies, Prof. Mirelman and her team were able to identify subtle gait and mobility alterations in the pre-clinical phase of PD. This work has led to the exploration of the role of genetics in gait and to the examination of potential phenotypic differences that could lead to understanding personal differences in disease trajectories. Prof Mirelman and her team published over 100 papers on markers of neurodegeneration and disease progression, she is an associate editor for Frontiers in Neurology and IEEE OJEMB. LEMON is home to software engineers, neurologists, computational analyst and data scientist, research assistants and several MSc and PhD students.
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