Einar M. Sigurdsson, PhD, is a Professor at New York University, Grossman School of Medicine. His research focuses on pathogenesis, therapy and diagnosis for Alzheimer’s disease and related disorders. His doctoral work provided one of the earliest evidence for amyloid-β induced tau pathology in a distant but anatomically connected brain region, providing an important insight into Alzheimer’s pathogenesis. During his postdoctoral and junior faculty years, Einar and his collaborators introduced the use of modified non-toxic amyloid-β derivatives as potential immunotherapy for Alzheimer’s disease. Furthermore, they showed for the first time that active and passive immunization as well as chelators delayed the onset of prion disease in mice. On the diagnostic front, Dr. Sigurdsson and colleagues published the initial report on detection of amyloid plaques in living mouse brains by magnetic resonance imaging. Subsequently, his laboratory provided the first reports demonstrating efficacy of active and passive tau immunizations, which has led to several clinical trials. He has published over hundred peer reviewed articles and book chapters, edited three books, serves as a journal editor, and is an inventor on several patents.
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