Sarosh Irani is a clinician scientist, Professor of Autoimmune Neurology and consultant neurologist, at the University of Oxford. His group aims to improve treatments and outcomes for patients with autoantibody-mediated diseases of the nervous system and understand the biology behind these rapidly expanding conditions.
Sarosh undertook clinical training in Oxford and London, with a DPhil in Oxford and a Fulbright postdoctoral position in UCSF. He has made several discoveries within the translational neuroimmunology space. These have spanned basic clinical observations, including description and refinement of clinical phenotypes associated with autoantibodies, detection of pathogenic autoantibodies, genetic findings and B cell immunobiology, all in the field of autoantibody-mediated diseases.
Clinically, he runs the UK’s major clinic for autoantibody related CNS diseases. He has recognised faciobrachial dystonic seizures in association with LGI1-antibodies, the importance of early immunotherapy in these patients, and distinctive psychopathological features associated with NMDAR-antibody encephalitis. In the laboratory, he has led the discovery of LGI1- and CASPR2-antibodies, their associated HLA associations and the roles of B cells in the pathogenesis of autoimmune forms of encephalitis and neuromyelitis optica.
He was awarded the Graham-Bull Prize in Clinical Science / Goulstonian Lectureship, from the Royal College of Physicians, and awards including the NIHR BRC Senior Clinical Fellowship and both Wellcome Intermediate and MRC Senior Clinical Fellowships.
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