EDUCATION & QUALIFACTIONS
CPsychol Statement of Equivalence in Clinical Psychology (British Psychological Society)
2000-2004 PhD Neuropsychology (Imperial College London; part time)
1996-1999 BA Experimental Psychology (University College, Oxford)
APPOINTMENTS AND AFFILIATIONS
6/2018- Professor of Neuropsychology, UCL Queen Square Institute of Neurology
10/2014-5/2018 Professorial Research Associate, UCL Institute of Neurology
10/2012-9/2014 Principal Research Associate, UCL Institute of Neurology
7/2010-3/2017 Alzheimer’s Research UK Senior Research Fellow, UCL Institute of Neurology
7/2010-7/2012 Clinical Psychologist, Hyperacute Stroke Unit, Northwick Park Hospital
10/2005-2/2010 Alzheimer’s Research Trust Research Fellow, Dementia Research Centre, UCL
8/1999-9/2005 Research Assistant, Dementia Research Centre, UCL/Imperial College London
Chair/Past-Chair, Alzheimer’s Association ISTAART Professional Interest Area (PIA): Atypical Alzheimer’s Disease and Associated Syndromes (2013-2019)
Commissioner, Commission on Dementia and Music (2017)
Committee Member, Dementia Advisory Group, British Psychological Society (2015-2017)
International Working Group for Alzheimer’s disease (2013-)
EU Joint Programme – Neurodegenerative Disease Research (JPND) cognitive working group (2014-)
Committee Member (2008-2010) & Meetings Secretary (2012-2014), British Neuropsychological Society
GRANTS & PRIZES
Principal Investigator/Applicant
2019-2023 ESRC-NIHR Dementia Programme Grant (£3.65m) The impact of multicomponent support groups for those living with rare dementias
2016-2018 Wellcome Trust, Hub Award (£1,000,000) Created Out of Mind: Shaping perceptions of dementia through art and science
2015-2018 Alzheimer’s Society (£278,850)“Am I the right way up?” Investigating balance problems in posterior cortical atrophy
2015-2018 Engineering and Physical Sciences Council (EPSRC) (£1,815,175) Computational PLatform for Assessment of Cognition In Dementia (C-PLACID)
2014-2018 ESRC-NIHR Dementia Programme Grant (£2,682,876)Seeing what they see: compensating for cortical visual dysfunction in Alzheimer’s disease
2010-2016 Alzheimer’s Research UK, Senior Research Fellowship (£575,691)
(renewed June 2013) Alzheimer’s Disease and Posterior Cortical Atrophy: cognitive and neuroimaging studies of visual dysfunction
Co-investigator
2020-2024 Alzheimer’s Association Strategic Award (PI: Jonathan Schott; $10,559,333) Harnessing seven decades of prospective data collection to understand the causes of cognitive decline and dementia: a deep phenotyping study of the British 1946 birth cohort
2014-2019 Alzheimer’s Research UK (PIs: Schott, Fox, Richards; £2,000,000)
A longitudinal amyloid-PET/MRI study of the MRC British 1946 birth cohort
Prizes
2015 Alzheimer’s Society Dementia Research Leader Award
2012 British Neuropsychological Society 10th Elizabeth Warrington Prize
SUPERVISION AND MANAGEMENT
Neuropsychology lead for Dementia Research Centre (>20 postdocs, research assistants and PhD students [10 current + 7 complete])
Member of UCL Dementia Strategy Board
Member of the Dementia Research Centre Executive, Strategy and Research Adoption committees
Lead, Rare Dementia Support (www.raredementiasupport.org)
Lead, Patient and Public Involvement for Queen Square Dementia Biomedical Research Unit (2013-2017)
RESEARCH CAREER SUMMARY
Seb Crutch’s recent research has focused on characterizing posterior cortical atrophy (PCA), the so-called ‘visual variant’ of Alzheimer’s disease (AD). His ongoing longitudinal study of PCA has enabled him to build the largest PCA cohort in the world leading to improved understanding of both dementia-related visual impairment in particular and the causes and consequences of atypical AD more generally. Key outputs have included launching an international working party and publishing international consensus statements on research criteria for PCA (Crutch et al., Alzheimer’s and Dementia, 2013, 2017) and atypical AD more generally (Dubois et al., 2014); a collaborative GWAS study identifying potential novel genetic risk factors for PCA (Schott et al., Alzheimer’s and Dementia, 2016); the first major longitudinal study of neuroimaging and cognition in PCA (Firth et al., Brain, 2019); the discovery of excessive ‘visual crowding’ (Yong et al., Brain, 2014; Cortex, 2013, 2014; Neurology, 2015); identification of disordered eye movement control in PCA (Shakespeare et al., Brain, 2015); and influential reviews of the syndrome (Crutch et al., Lancet Neurology, 2012; Schott and Crutch, Continuum, 2019).
He has developed a number of interdisciplinary research themes collaborating with experts in social science, environmental engineering, occupational health and ophthalmology (in ESRC/NIHR funded work to ameliorate the effects of vision loss in dementia), computational statistics, virtual environments and human-computer interaction (in EPSRC funded work to enhance cognitive assessment in ageing and disease), neurorehabilitation (in Dunhill Medical Trust funded work to design an app to facilitate reading in PCA), neurophysiology, engineering and neuro-otology (in Alzheimer’s Society funded work to understand balance problems in PCA), and philosophy and linguistics (to advance research into the brain basis of abstract conceptual knowledge).
From 2016-2018, he directed the Created Out of Mind residency at The Hub, Wellcome Collection, bringing together artists, scientists and people living with dementia in a collaboration of over 60 individuals, institutions and charities aiming to shape and enrich public and professional perceptions of the dementias, and explore the opportunities afforded by collaborative, interdisciplinary, publicly-situated research.
He currently leads a 5-year ESRC-NIHR research programme evaluating the impact of support groups (http://www.raredementiasupport.org/) that mix peer and professional experience.
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