Dr. Ziai is Professor of Neurology, Neurosurgery, and Anesthesia/Critical Medicine at the Johns Hopkins Medical Institutions in Baltimore Maryland. She is co-Chair of Neurocritical Care Research Central (NCRC) and of the Grants Subcommittee of the Neurocritical Care Society (NCS). She is an Associate Editor for the journal Neurocritical Care.
Dr. Ziai’s research is focused on mechanisms of injury and recovery in intracerebral hemorrhage (ICH) with a focus on multicenter clinical trials of minimally invasive surgery to treat hemorrhagic stroke. She has managed clinical and administrative aspects of several international phase 3 trials testing clot reduction strategies for ICH (MISTIE II and III trials: minimally invasive surgery plus alteplase in the treatment of ICH) and IVH (CLEAR IVH trials: Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage). Organizational roles in the CLEAR IVH and MISTIE III trials included Chair of the Safety Event Committee. She collaborates with North American and international groups investigating the role of MIS strategies with fibrinolysis in ICH and IVH and also as a clinical trialist in safety management and adjudication of such events in other clinical trials of high-acuity brain-injured patients. She coordinated the MISTIE III ancillary study, “Mechanisms of Tissue Injury in MIII,” an international collaboration evaluating leukocyte and inflammatory markers in ICH. She is currently PI of the REASSESS ICH study (Repeated Assessment of Survivors in Intracerebral Hemorrhage), which will determine if reducing hematoma volume with minimally invasive surgery for ICH decreases the risk of progressive cognitive decline.
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